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Naming Nucleotides and Nucleosides



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in this video I want it's like a little

bit about naming nucleotides and

nucleosides sometimes they can get a

little bit tricky so I kind of want to

go over it briefly that way in case I

reference them at any point later on

that it makes sense

so if we have nucleus sides right we

charge is just a pentose sugar with some

nitrogenous base well these are the

nitrogenous bases here so if they're

attached to a ribose they would be

nucleosides in the case of adenine being

the base if it was ribose plus adenine

it would be called a denno scene okay

now if it was ribose and the guanine it

would be guano seen so the two purines

adenine and guanine are named similarly

you basically just added an OC n-- okay

in the case of uracil and cytosine which

are both per immanence they become your

Adeem right sounds like pyrimidine and

site to Dean right this is a ribose with

a uracil attached to it and this is a

ribose with a cytosine attached to it

they'd become Yura Dean and cited

respectively now what if you have I mean

notice I've written in yellow and I put

a pink star next to it so now if I mean

attached to a deoxyribose would be cyma

Dean and find me doesn't attach to

ribose because thymine is only in DNA

right so if you recall DNA having AST

season G's and RNA having a is used

season G's thymine is only in DNA so it

could only be a deoxy nucleoside so it

is called thymidine okay but more

specifically or precisely it's deoxy

thymidine and that's but that's

it always had the deoxy it's only in DNA

right so that's what I want to right

here right Simon is only deoxy so it's

because it's only in DNA not RNA so for

all of these other ones here

all of these other nucleotides these are

ribonucleotides on their identity and

wanna senior 18 inside a Dean they can

also if you want to make these deoxy if

the sugar is instead of ribose it's

deoxyribose all you have to do these

names is put a deoxy in front of them as

a prefix so this would be deoxyadenosine

or deoxy guanosine deoxy or a Dean deoxy

cited date now fly me Dean is Lima Dean

and the academic dean are the same thing

which is why I feel like more

comfortable just calling it deoxy time'

Dean because this saying this Lima Dean

is kind of confusing and maybe

misleading so keep that in mind now what

if we have nucleotides well if you

recall I mentioned in the previous video

that nucleotides are just nucleoside

phosphates so they're just a nucleoside

with phosphate groups attached to them

and I said that you could add 1 2 or 3

phosphates to the 5 prime carbon of the

sugar so in the case of nucleotides you

basically just give it the nucleoside

name and then put a 5 prime and then the

blank here and then a phosphate now what

can go in this blank well that depends

on the number of phosphates so if you

had adenine attached to ribose and you

had one phosphate group at the 5 prime n

it would be adenosine for the name for

the nucleoside and then if it only had

one phosphate at the 5 prime end it

would be called mono phosphate if I had

two it would be diphosphate so identity

in five prime diphosphate or adenosine

five prime triphosphate if there are

three phosphates so it's the same thing

for these other ones here you just give

it a nucleated in the nucleoside name

and then five prime and then however

many phosphates there are right so with

thymidine you don't give it that name

right you would only give it the deoxy

name so it would be

oxi thymidine five prime and then

however many phosphates again because

you would not find this in RNA it's an

old it's not a ribonucleotide it's a

deoxyribonucleotide only okay so now

that we've gone over these names let's

kind of put this in into perspective by

talking about a few examples so if you

were asked to draw a DA MP which is

deoxy adenosine monophosphate right or

it's more specifically deoxyadenosine 5

prime mono phosphate so the deoxy the

deoxy means that you're going to have

your sugars and the VD oxy ribose and we

know that because of this here right

this 2 prime carbon on the ribose sugar

has no Oh H group has just the age group

so that's the deoxy now at the 1 prime

carbon we have the base and in this case

it's editing because it's called

adenosine so this adenine is attached

here at this nitrogen and then at the 5

prime carbon right up here we have we

should have one phosphate group so I've

drawn one phosphate group so this was

deoxy adenosine 5 prime mono phosphate

now what if you're asked to draw UTP

which is your Adeem 5 prime triphosphate

well so there's no deoxy so we would

expect the ribose right so that's why we

have this o H here instead of an H at

the two prime carbon and then of course

it's your a diene so we've the the

nitrogenous base attached to the 1 prime

carbon should be uracil that's what we

have here and at the 5 prime n we should

have 3 phosphate groups so there's 1 2 3

phosphate groups

so that's UTP now what about guanosine

well guanosine is just a nucleoside

right so up here these were both

nucleotides ones just this is a

ribonucleotide up here this is a

deoxyribonucleotide so now here we just

have a nucleoside so there's no

phosphate groups

so in guanosine this is not deoxy so

here we have an O H instead of an just

an H and at the 1 prime carbon of the

ribose we should have a guanine

nitrogenous base and that's what we have

here if we get attached at the correct

nitrogen in the case of deoxy cited Dean

well deoxy right so we have the H there

at the two prime carbon the office

excited eating there's no phosphates

right this is a new Clio to me a

ribonucleoside and ch2oh over here right

cuz there's no phosphate groups and then

cited e means that the the nitrogenous

base was cytosine which is what we have

here alright that's pretty much it I

hope that was helpful in a sort of

overview kind of way that's a bit that's

it I hope you find that helpful

one last thing I am a tutor if you live

in Southern California feel free to

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